want to take a B-12 supplement. Babies with methylmalonic acidemia are unable to convert methylmalonyl CoA to succinyl CoA. This is an uncommon metabolic disorder in which your body can't process It can also cause signs and symptoms of neuropathy, such as numbness and tingling in the hands and feet and/or, in advanced cases, mental or behavioral changes such as cognitive impairment, confusion, irritability, and depression. When present in sufficiently high levels, methylmalonic acid can act as an acidogen and a metabotoxin.
If the kidneys are not functioning properly, they cannot properly eliminate methylmalonic acid in the urine, causing methylmalonic acid to accumulate in the blood.A decreased level of methylmalonic acid is not common and is not considered clinically significant.There are currently no guidelines for screening asymptomatic adults for vitamin B12 deficiency, but confirmation with methylmalonic acid and/or homocysteine may be necessary for those at high risk without symptoms, such as the elderly, or when certain medications have been taken for a long time.If your vitamin B12 test result is in the lower end of the normal range and you do not present with significant clinical symptoms, your healthcare provider may feel that you have adequate vitamin B12 and will rely on these findings rather than an elevated methylmalonic acid. Infants may have abnormal levels of MMA because of a condition called methylmalonic Your test results may not mean you have a problem. Your body makes large Abnormal MMA levels are common in pregnancy. Afterward, the site may be sore.
The disease is usually Others believe that methylmalonic acid and homocysteine (which may also be elevated when either B12 or folate is deficient) are valuable in detecting early and mild cases of B12 deficiency. higher risk for a B12 deficiency. MMA is excreted through
It may be ordered by itself or along with a homocysteine test as a follow-up to a vitamin B12 test result that is in the lower end of the normal range.If only the homocysteine level is elevated and not methylmalonic acid, then the person may have a folate deficiency. deficiency. If there is not enough B12 available, then the methylmalonic acid level begins to rise, resulting in an increase of methylmalonic acid in the blood and urine. Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production. acids may also be done if the provider thinks that a child may have this condition.
Screening for this disorder is part of mandatory programs in all 50 states in the U.S. This test measures the level of MMA in blood or sometimes urine. Vitamin B-12 deficiency is the ©2020 University of Rochester Medical Center Rochester, Test results may vary depending on your age, gender, health history, the method used In one step of metabolism, vitamin B12 (cobalamin) promotes the conversion of methylmalonyl CoA (a form of methylmalonic acid) to succinyl Coenzyme A by methylmalonyl-CoA mutase in a reaction that requires vitamin B12 as a cofactor. amounts of MMA if you have a drop in the amount of vitamin B-12.
They appear normal at birth, but as they consume protein, they begin to show symptoms such as excessive tiredness, vomiting, dehydration, weak muscle tone, seizures, mental retardation, strokes, and severe metabolic acidosis most common cause of MMA production. bruising, and feeling lightheaded. Methylmalonic acid is a malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. blood.
35. Methylmalonic acid exists as a solid, soluble (in water), and a moderately acidic compound (based on its pKa). acid) concentrations. for the test, and other things. Your body needs B-12 to make red blood cells and to help your central nervous system These are also the characteristic symptoms of the untreated inborn errors of metabolism mentioned above. If your homocysteine In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures.Normal value ranges may vary slightly among different laboratories. A high level MMA is typically made in tiny amounts when you digest protein.
go back to normal after treatment with B-12. This is when your body does
Measuring methylmalonic acid in the blood or urine can help detect early vitamin B12 deficiency.Moderately to severely elevated levels of methylmalonic acid may be seen in infants with the rare inherited disease methylmalonic acidemia.The methylmalonic acid blood test measures the amount of methylmalonic acid in the blood. acidemia. These peri… Some studies have found a high variation in methylmalonic acid levels when they are measured over time.Methylmalonic acid is usually ordered, sometimes along with a homocysteine test, when a vitamin B12 test result is in the lower portion of the normal range, especially when a person has symptoms associated with B12 deficiency.Methylmalonic acid is an organic acid and abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis.
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